Boiware teased us on all the lead up to Mass Effect 2's release that the series' leading character, Commander Shepard, had been Killed in Action. It was certainly a clever way of building a sense on intrigue around the game, because one of the major USPs that Bioware promoted with the original Mass Effect was that this was the first part of a trilogy, with story choices made in previous games having a bearing on the story of sequels. Killing off a major character between games kinda made it seem like they were going back on the idea, but all became clear during the first fifteen minutes of Mass Effect 2.
I love this opening because it's a fine example of Bioware at their best. It's paced very well; a mysterious conversation, a quick catch up with the characters from the original, and then disaster, and a perfectly pitched selfless hero moment. It's also wonderfully directed Sci-Fi.